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4 October, 2007 - Merck's Investigational CETP-Inhibitor, MK-0859 - anacetrapib
Merck & Co. announced today that Phase IIb study results showed that anacetrapib significantly reduced LDL-cholesterol (LDL-C) and increased HDL-cholesterol (HDL-C) both alone and in combination with atorvastatin 20 mg compared to placebo in patients with primary hypercholesterolemia or mixed hyperlipidemia. Several dosages were tested during the eight week study, including 10, 40, 150 and 300 mg. LDL-C levels were reduced 16%, 27%, 40% and 39% and HDL-C levels were increased 44%, 86%, 139% and 133% respectively. Dosages were also tested in combination with atorvastatin and produced significant incremental reductions in LDL-C and increases in HDL-C when compared to atorvastatin alone. All told, there were 10 separate studied groups, including 4 various dosages with anacetrapib alone, 4 with a combination of various dosages with anacetrapib with 20mg atorvastatin and two placebo. Another bright spot - there was no significant indication of raised blood pressure during the test.

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